The Indians three-game win streak evaporated on a Wednesday afternoon in Chicago. Alex Rios hit a two-run homer and the Chicago White Sox edged the Indians 3-2.
The win ended the White Sox four-game losing skid.
Jeff Keppinger drove in one run for the Pale Hose but it was an Alex Rios two-run homer that proved to be the difference in the win.
Jose Quintana upped his record to 2-0 while being charged with two runs and four hits in his five-plus innings on the hill.
Zach McAllister was trailing 1-0 in the fifth inning when Rios connected on the two run blast.
McAllister (1-3) walked five and allowed five hits in 5 2/3 innings. Four relievers then combined for 2 1/3 innings of hitless ball, giving the Indians a chance to rally.
The Indians got two runs back in the sixth inning on a Kipnis RBI and a Reynolds Sacrifice fly, but the rally fell short when Nick Swisher struck out for the second out and Ryan Raburn flew out to end the threat.
The Indians are off on Thursday.