Francona, 61, has a medical procedure scheduled this week and Sandy Alomar Jr. will manage in his place. The club expects the manager to rejoin the Tribe on Friday for the series against Detroit.
Francona missed eight games while dealing with lingering gastrointestinal issues. He was in the dugout for the two-game series against the Chicago Cubs.
In other Tribe news, catcher Sandy Leon left the team for a family emergency and will be out for at least three days. Outfielder Greg Allen was called up to fill his roster spot. Catcher Roberto Perez was also activated on Tuesday.
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