The Cardinals will also be without quarterbacks coach Cam Turner and defensive lineman Zach Allen, who both tested positive for the virus.
Arizona will divide head coaching duties among defensive coordinator Vance Joseph and assistant head coach/special teams coordinator Jeff Rodgers.
Cleveland is 3-2 and coming off a 42-47 loss to the LA Chargers, while the Cardinals have yet to lose this season. The Browns won’t have star running back Nick Chubb, who is out with a calf injury.
“Anytime you are without a player of Nick’s caliber, guys have to step up. It is never one person who replaces Nick Chubb. Obviously, we feel real strong about Kareem (Hunt) and what he is capable of, but guys have to step up,” Cleveland head coach Kevin Stefanski said.
The game kicks off at FirstEnergy Stadium at 4:05 p.m. You can catch all the action on FOX 8.