It happened just before 4 p.m. on Wood Avenue SE, near Hillvale Street NE in Osnaburg Township.
According to state troopers, a 2016 Subaru Impreza was heading northbound on Wood Avenue when it went left of center, hitting a Ford van heading the opposite direction.
The Subaru driver, 22-year-old Ava Burman, of Minerva, was taken to the Cleveland Clinic Mercy Hospital. She was pronounced dead at the hospital.
The van driver and a passenger sustained non-life-threatening injuries.
Drugs and alcohol were not factors in the crash. Everyone involved was wearing a seatbelt, state troopers say.