Police initially reported two separate crashes just after 2 p.m. Tuesday.
Police Capt. Mitch Houser said one man was killed and several other injuries were reported.
A child was also injured but was treated at the scene by paramedics and was not taken to a hospital.
Since the crashes, one lane along Lakeland Boulevard and two lanes along I-90 East have been reopened.
The Babbitt Road exit along I-90 East was closed for several hours. But it later reopened, the Ohio Department of Transportation announced on Twitter just before 6 p.m. Tuesday.