It happened in the 13600 block of Rugby Road, which is near the intersection of Rodman Court, according to preliminary information from Cleveland police.
The Cuyahoga County Medical Examiner identified the person killed as 17-year-old Marcel Martin of Cleveland. He was in a vehicle near the intersection, according to the office.
He was declared dead at the scene, according to Cleveland EMS.
EMS workers also transported a 21-year-old man to a local hospital in critical condition.
Police on Thursday said the investigation was in its early stages.