It happened just after 3:30 p.m. at the intersection of Criswell Road and Salt Creek Road in Salt Creek Township.
According to investigators, the teens on the dirt bike were heading north on Criswell Road when the driver of a gray 2017 Chrysler Pacifica failed to yield at a stop sign.
State troopers say the dirt bike then ran into the Chrysler, throwing the 16-year-old driver and a 15-year-old passenger from the bike onto the road.
The driver was pronounced dead at the scene.
The passenger was taken by firefighters to a landing zone and flown by Life Flight to Akron Children’s Hospital. He later died from his injuries.
Investigators don’t believe alcohol was a factor in the crash. They said the dirt bike driver and passenger weren’t wearing helmets at the time.
The fatal crash remains under investigation.