Around 3:30 a.m., troopers say a semi-driver sideswiped a vehicle that was parked on the shoulder of the Turnpike between Route 57 and I-480.
The semi continued off the roadway and hit a guardrail and a bridge pillar at the State Route 83 overpass.
The semi-driver was trapped and was pronounced dead at the scene.
The driver of the car parked on the shoulder suffered minor injuries.
The identity of the semi-driver has not been released, pending notification of next of kin.
The westbound lanes of the Turnpike were closed for about 3 hours.
OSHP urges drivers to find a rest area or other safe place to stop if they find themselves drowsy behind the wheel.