Officers responded just after 11:30 p.m. to the home in the 3100 block of West 54th Street, where victim and the suspect were reportedly fighting just before the shooting, according to a news release.
The 21-year-old suspect shot the 41-year-old man then fled. The victim had suffered multiple gunshot wounds and later died at a hospital, according to police.
The homicide remains under investigation. No arrests have been made.