It happened just before 6 p.m. Tuesday.
Troopers responded to State Route 51 north of State Route 795.
According to a press release, a driver in a Hyundai Elantra headed northbound on SR-51 went left of center and hit another car head-on.
The Elantra driver was not wearing her seatbelt, according to OSHP, and was killed.
She’s been identified as Erin E. Mason, 36, of Toledo.
A woman from Genoa was in the other vehicle.
She was taken to the hospital with non-life-threatening injuries.
The crash remains under investigation.