The Associated Press said his family announced his death from complications from the coronavirus.
Prine, a country folk-singer and songwriter for nearly five decades, was hospitalized at Vanderbilt University Medical Center on March 26. He had since been placed in ICU and put on a ventilator and reportedly had pneumonia in both of his lungs.
The two-time Grammy-winner is perhaps best known for songs such as Sam Stone, Hello in There, Angel From Montgomery, Your Flag Decal Won’t Get You Into Heaven Anymore, The Late John Garfield Blues, Bear Creek Blues, Sweet Revenge, and Spanish Pipedream.
He sang his conversational lyrics in a voice roughened by a hard-luck life, particularly after throat cancer left him with a disfigured jaw.
He joked that he fumbled so often on the guitar, taught to him as a teenager by his older brother, that people thought he was inventing a new style. But his open-heartedness, eye for detail and sharp and surreal humor brought him the highest admiration from critics, from such peers as Bob Dylan and Kris Kristofferson, and from such younger stars as Jason Isbell and Kacey Musgraves, who even named a song after him.
In 2017, Rolling Stone proclaimed him “The Mark Twain of American songwriting.”
Prine was 73 years old.