Okoro, who scored 23 points and delivered a highlight-reel dunk over three Houston players on Wednesday night, will be out for an undetermined period.
The Cavaliers said his status will be updated “at the appropriate time.”
One of the team’s best defensive players, the 20-year-old has scored at least 16 points in his last four games while helping the surprising Cavs reel off five straight wins and improve to 18-12.
The Cavs have been encouraged by Okoro’s development on the offensive end.
Cleveland plays at Milwaukee on Friday night.